Small Forgotten Places in the Hearth of Cities

This book is the result of a research project designed and carried out at the Department of Architecture, University of Florence. This book discusses urban public spaces and, more specifically, run-down, inactive micro-spaces that are barely used due to their location, dimensions, morphology or semantic characteristics. In literature, these spaces are often defined as “residual urban spaces.” A large abandoned industrial area on the outskirts of a town or a small interstitial space in a historical centre can be residual. With respect to such a broad subject matter, the book seeks to radically limit the field, concentrating on public residual spaces found in the oldest parts of cities. The book reflects on this theme and introduces a method for reading and assessment of the residuality of public spaces in historical contexts (Residuality Assessment Process) which was tested in the historical centre of Florence. It is the authors’ view that residual spaces, above all if designed according to a system logic, can go from being problems to potential activators of urban and social regeneration processes, offering a useful contribution to improve city life

Turismo accessibile a Mondovì: proposte per il miglioramento dell’accessibilità

Mondovì Piazza, the ancient center of the city of Mondovì (CN), constitutes architectural and cultural heritage of considerable interest, which, despite its considerable potential for tourism development, is undergoing a significant demographic decline. The Italian Network of Accessibility Lab in cooperation, promoted, in 2016, an international workshop regarding ideas to improve the accessibility to services of a morphologically complex area, with the aim of collaborating with the local Municipality in an overall action for tourism enhancement with a focus on accessibility. During the workshop students in architecture and design from the universities participating in the accessibility Lab network, tackled an immersive design experience centered on accessibility issues with an original approach, face to face with the problems, the stakeholders, and a team of experts. The immersive workshop training experience was better than ordinary university courses, and allowed students to understand better the complexity of architecture and urban design and to learn a design approach based on real needs. The paper illustrates the results of the workshop both in terms of design proposals and learning outcomes, suggesting this kind of experience as the most appropriate to deal with cultural heritage accessibility issues

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer

Purpose: Data from epidemiological and experimental studies suggest that dietary protein intake may play a role in inhibiting prostate and breast cancer by modulating the IGF/AKT/mTOR pathway. In this study we investigated the effects of diets with different protein content or quality on prostate and breast cancer. Experimental Design: To test our hypothesis we assessed the inhibitory effect of protein diet restriction on prostate and breast cancer growth, serum PSA and IGF-1 concentrations, mTOR activity and epigenetic markers, by using human xenograft cancer models. Results: Our results showed a 70% inhibition of tumor growth in the castrate-resistant LuCaP23.1 prostate cancer model and a 56% inhibition in the WHIM16 breast cancer model fed with a 7% protein diet when compared to an isocaloric 21% protein diet. Inhibition of tumor growth correlated, in the LuCaP23.1 model, with decreased serum PSA and IGF-1 levels, down-regulation of mTORC1 activity, decreased cell proliferation as indicated by Ki67 staining, and reduction in epigenetic markers of prostate cancer progression, including the histone methyltransferase EZH2 and the associated histone mark H3K27me3. In addition, we observed that modifications of dietary protein quality, independently of protein quantity, decreased tumor growth. A diet containing 20% plant protein inhibited tumor weight by 37% as compared to a 20% animal dairy protein diet. Conclusions: Our findings suggest that a reduction in dietary protein intake is highly effective in inhibiting tumor growth in human xenograft prostate and breast cancer models, possibly through the inhibition of the IGF/AKT/mTOR pathway and epigenetic modifications

A South African <i>Convivio</i> with Dante

This book offers a collection of South African university students’ written responses to the Commedia and scholars’ commentary on them. The students’ collection includes writings of all genres and subjects: prose, poetry, personal reflection, dialogue, non-fiction based on the first two cantiche of the Commedia. Some are autobiographical and others are fictional stories, but they all have in common a very personal (and South African) approach to Dante’s text. The scholarly essays of the second part are concerned with the unusual way in which Dante is appreciated by our youth: not as a remote figure only encountered in the hallways of the literature department, but as an intimate presence, a guide, a friend whose language is familiar and invites a response